(21)吸烟和患认知症的风险-Smoking and Dementia Risk-公开课-关爱惟士
(21)吸烟和患认知症的风险-Smoking and Dementia Risk

课程视频:http://player.youku.com/embed/XMjY3ODM2NTEyOA




Professor Kaarin Anstey

Kaarin Anstey教授


We conducted what we call a “meta-analysis” of the smoking literature. We collated all of the published studies that observed smoking, and then followed people to see whether or not they developed cognitive decline, Alzheimer's disease, vascular dementia or all-cause dementia. And we found that smoking in older adults increased their risk of dementia by 70%. And it was pretty much the same for all types of dementia.

我们做了我们所谓的有关吸烟的文献的荟萃分析。我们收集了所有观察吸烟的已发表的研究论文,然后随访他们看看是否后来发展为认知下降,阿尔茨海默病,血管性认知症或所有原因引起的认知症。然后我们发现老年人吸烟会使他们患认知症的风险增加70%,这在所有类型的认知症中是很高的风险了。


Now, unfortunately, we didn’t have the data from middle age to be able to see if that was true of midlife smokers and what happens if people give up. There is one very interesting study that was conducted in Western Australia, on a group of people who entered a smoking cessation program. They took brain scans of these people at the beginning of the program and at the end, and they also tested their cognition. What they found was that the people who gave up smoking had less brain atrophy than the people who continued to smoke. And they also found that people who gave up smoking had less cognitive decline. So that study is really important in showing there are actually benefits for the brain, even giving up smoking in older age.

现在,不幸的是,我们还没有中年期的数据来观察中年吸烟者是否也这样,还有如果他们戒烟会怎么样。在西澳进行过一个非常有趣的研究,一群人参加了戒烟行动。他们在行动开始时和结束时分别做个脑部扫描,并做认知能力测试。他们发现戒烟的人和继续吸烟的人有较轻的脑萎缩。他们还发现戒烟的人认知退化少。这项研究十分重要,因为它表明即使在老年期戒烟也会对大脑有好处。


Smoking impacts on the brain through multiple pathways. We know that smoking increases the rate of ageing on all of the biomarkers that we can measure. Smoking increases the risk of vascular events, so small strokes and stroke. It increases the rate of brain atrophy. It’s a neurotoxin, and of course it increases the risk of a lot of other diseases such as cancer, which can also ultimately impact on the brain. So it’s a pretty general negative risk factor, a negative behaviour to undertake for brain ageing.

吸烟从多种途径来影响大脑。我们知道吸烟增加了我们能测量的关于衰老速度的所有生物指标。吸烟增加了发生像小中风和中风这样的血管事件的风险。它增加了脑萎缩率。它是神经毒剂,理所当然地增加很多像癌症之类的其它疾病,从而最终影响大脑。所以它是一种常见的负风险因素,是承担大脑衰老的负面行为。


翻译:关爱惟士-未经允许不得转载,违者必追究法律责任

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